Canagliflozin
General English name: Canagliflozin
Brand: Invokana®, Vokanamet
Application: Type 2 diabetes in adults over 18 years
Pharmaceutical forms of canagliflozin
Combination brand containing canagliflozin
Canagliflozin Drug Information
Dosage and method of taking canagliflozin
Contraindications to the drug canagliflozin
Consumption of canagliflozin during pregnancy and lactation
The effect of canagliflozin on driving and working with machines
Drug Interactions Canagliflozin
Special warnings and precautions while taking canagliflozin
Side effects of canagliflozin
Overdose of canagliflozin (drug poisoning)
Storage conditions of canagliflozin
Pharmaceutical forms of canagliflozin
ombination brand containing canagliflozin
- Vokanamet: Canagliflozin and metformin
Canagliflozin Drug Information
Insulin is a hormone that is naturally made in the body by the pancreas. This helps control blood sugar levels. If your body does not make enough insulin to meet its needs, or if it does not use the insulin it makes effectively, a condition called diabetes mellitus (diabetes mellitus) develops. People with diabetes need treatment to control the amount of glucose (sugar) in their blood; Because good blood sugar control reduces the risk of further complications. Some people have their blood sugar controlled by making changes in their diet, but to control their blood sugar in others, medications such as canagliflozin are prescribed along with dietary changes and regular exercise.
Canagliflozin affects the kidneys and increases the sugar that the body transports to the urine, lowering blood sugar levels.
Dosage and method of taking canagliflozin
- Read the package leaflet carefully before starting treatment with canagliflozin. This brochure will help you to get comprehensive information about the drug and its possible side effects.
- The dose and amount of canagliflozin varies from person to person; Use the medicine exactly as your doctor advised. The usual starting dose is one 100 mg tablet daily. If the low dose is well tolerated, the dose may be increased to 300 mg once daily. Take the pill with water (it is better to take this pill only before the first meal of the day). Try to take your dose every day, at the same time of day.
- If you have been prescribed a combination of canagliflozin with metformin (Vokanamet brand), you should take the pill twice a day. Take the pill after a meal or snack as this will reduce the risk of stomach pain.
- The combination drug canagliflozin (Vokanamet) is available in pharmacies in several different strengths (doses), make sure that when you buy the medicine, the pharmacist will give you the medicine that your doctor has prescribed for you.
- If you forget to take your daily dose at the scheduled time but soon forget (less than 12 hours left until your next dose), take the medicine; But if you remember when the next dose is near the hour, do not take the missed dose. You should not take two doses of the medicine together because of the missed dose.
Contraindications to the drug canagliflozin
- Note the expiration date of the canagliflozin drug and do not take it if it has expired.
- Never give canagliflozin to another person, even if you have the same symptoms.
- Check for drug interactions, and if you are taking a drug that interacts with this medication, talk to your doctor about using your medications.
Consumption of canagliflozin during pregnancy and lactation
During pregnancy and lactation, you should not use the drug arbitrarily without consulting your doctor. Medications can have devastating effects on the fetus or on yourself.
The effect of canagliflozin on driving and working with machines
Canagliflozin may make you dizzy or drowsy, so make sure you are alert before driving or operating machinery. You may have hypoglycemia due to the use of this drug and driving may not be suitable for you.
Drug Interactions Canagliflozin
Drug interactions may alter drug performance and increase the risk of serious side effects. Make a list of all the medicines (including prescription / over-the-counter and herbal medicines) you use and share them with your doctor and pharmacist. Do not change the dose of your medicine without consulting your doctor or stop taking the medicine.
Other medications can affect the removal of canagliflozin from your body and may affect the function of canagliflozin; These include rifamycins (such as rifampin, rifabutin), specific seizures (such as phenobarbital, phenytoin), and ritonavir.
Beta-blockers (such as metoprolol, propranolol, glaucoma eye drops such as thymolol) may prevent heart palpitations, which are commonly felt during hypoglycemia. Other symptoms of low blood sugar, such as dizziness, hunger, or sweating, are not affected by these medications.
Many medications can affect your blood sugar levels and make it difficult for you to control your blood sugar. Before you start, stop, or change any medication, talk to your doctor or pharmacist about how to take the medicine (the medicine that works on your blood sugar level). Check your blood sugar levels regularly and consult your doctor if you notice a sudden change in your blood sugar (high or low blood sugar). If you have serious side effects, talk to your doctor about changing your medication dose, exercise program, and diet.
If your urine glucose is positive, tell your lab staff that you are taking this diabetes medicine.
Special warnings and precautions while taking canagliflozin
Some medications may not be prescribed under certain conditions, and some medications may be prescribed if additional treatment is needed; Therefore, it is best for your doctor to be aware of the following before taking canagliflozin:
- If you are pregnant or planning to become pregnant, or if you are breast-feeding.
- If you have any kidney or liver problems.
- If your blood pressure is low.
- If you have a cardiovascular problem or heart failure.
- If you have a history of recurrent urinary tract infections.
- If you are taking certain medications. These medicines include all the medicines available, whether you are prescribed them or taking them without a doctor's prescription, such as herbal medicines and complementary medicines.
- If you have a history of an allergic reaction to a drug.
Side effects of canagliflozin
All medications can cause side effects. But many consumers also do not experience any side effects. Some of the side effects go away after a short time of taking the medicine. In case of persistent side effects, the physician should be informed:
- Symptoms of hypoglycemia (hypoglycemia) such as feeling tight or anxious, sweating, feeling hungry, palpitations, dizziness: Eat sweets quickly, such as biscuits or sugary drinks, and tell your doctor if you notice any of these symptoms.
- Urinary tract infections, frequent urination, or an urgent need to urinate: Drink plenty of fluids to replace lost water in your body, and talk to your doctor if these symptoms become uncomfortable.
- Genital Infections: If you have recurrent fungal infections that can be a sign that your blood sugar level is out of control, be sure to discuss this problem with your doctor and ask him or her to prescribe the right medication to relieve your symptoms. .
- Constipation and thirst: Drink a few glasses of water every day.
- Nausea (vomiting): Try to take your pill with food. See your doctor if this complication bothers you.
- Changes in some blood tests
Important Note: In rare cases, treatment with canagliflozin can increase the levels of certain chemicals in your blood, such as ketones. This can lead to a serious condition called diabetic ketoacidosis. If you notice any of the following symptoms in yourself, talk to your doctor immediately:
- A sweet or metallic taste in your mouth or another odor in your sweat or urine
- Feeling weak or sick (vomiting), abdominal pain
- Rapid weight loss, feeling thirsty, abnormal or difficult breathing (shortness of breath)
- Fatigue or drowsiness
Consult your doctor if you have any other symptoms that you feel may be due to canagliflozin.
Overdose of canagliflozin (drug poisoning)
- Do not take canagliflozin more than the dose prescribed by your doctor.
- If you feel that a person has drug poisoning and you have symptoms such as severe hypoglycemia, chills, shortness of breath or fainting (fainting), call the emergency room right away.
Storage conditions of canagliflozin
- Keep the medicine out of the reach of children.
- Keep the medicine in a cool, dry place away from heat and direct sunlight.